Polly Matzinger e seu co-autor.

Interessante aparecer comentário sobre uma cientista na imprensa leiga. Aldina me enviou um sobre Polly Matzinger:
"Antes de ser cientista, Polly Matzinger teve uma carreira incomum. Foi coelhinha da Playboy, garçonete, música de jazz, carpinteira e treinadora de cães.

Como cientista, entretanto, ela teve sérios problemas com o editor da revista científica. Ele, após fazer restrições preconceituosas ao nome de Galadriel Mirkwood no primeiro trabalho"

Veja o post completo no Blog do Nassif (aqui).

Curso de Bioestatística

Vaga PD na Scripps: Molecular Basis of Protein Quality Control and Neurodegeneration

SEPTEMBER 2013: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell and Molecular Biology, The Scripps Research Institute (San Diego, California).
Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease. The position available is to elucidate mechanisms and critical biological functions of Listerin, an E3 Ubiquitin Ligase implicated in Protein Quality Control and Neurodegeneration.
We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, an E3 ligase whose function was unknown at that time (Chu et al. 2009). Homozygous lister mice are born normal but exhibit early-onset and progressive neurological and motor dysfunction. The focus of our subsequent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of S. cerevisiae and found that the E3 is ribosome-associated and functions in the quality control of aberrant nascent proteins (Bengtson & Joazeiro 2010). Currently, our lab undertakes different approaches (such as biochemistry, yeast genetics, structural biology, mammalian tissue culture and genomics) to continue characterizing Listerin/Ltn1, and we are well-positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:
 Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.
 Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in
neurodegeneration. PNAS 106:2097-103.
 Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin
ligases. Annu Rev Biochem. 78:399-434.
The candidate is expected to be proactive and productive, and should have strong background in biochemistry and molecular biology.
Please send CV, a paragraph on current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro (Email: Joazeiro@scripps.edu) or Lorraine Lathrop (Email: llathrop@scripps.edu) The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd, La Jolla, CA 92037 

Vaga Pós doutorado na Scripps: Descoberta de drogas anti-cancer

SEPTEMBER 2013: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Molecular and Cell Biology, The Scripps Research Institute (San Diego, California).
Research in the laboratory addresses mechanisms of ubiquitination and the role of E3 ubiquitin ligases in biology and disease. This position is to carry out work as part of a multi-disciplinary collaborative team to (1) develop in vitro assays to identify inhibitors of E3 ligases from small molecule compound collections that we have generated; (2) subsequently validate the identified inhibitors all the way to therapeutic efficacy in animal models (cancer xenografts); and (3) utilize identified inhibitors as tools to study the biology of the target E3 and to elucidate molecular mechanisms of ubiquitination.
Selected references:
 Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.
 Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399-434.
 Li W et al. 2008. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3(1):e1487.
The candidate should have strong conceptual and experimental background in biochemistry and molecular biology, including at least some of the following: recombinant protein expression and purification, enzyme kinetics, and mammalian cell culture. Expertise in the mechanistic dissection of signaling or in cancer biology and signaling is also desirable, but not required. He/she should be proactive and productive, have excellent communication skills, and desire to work in a fast-paced, multi-disciplinary collaborative team.
Please send CV, a paragraph of current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro (Joazeiro@scripps.edu) The Scripps Research Institute, CB-163 10550 N Torrey Pines Rd
La Jolla, CA 92037 USA 

Seu artigo está preparado para ser ser “achado” pelos programas de busca?

A “visibilidade” no mundo virtual das publicações científicas é muito influenciado pela possibilidade de serem encontrados ao se realizar uma busca por artigos. Este assunto tem sido discutido ocasionalmente e recentemente Anne-Marie Green fez um post interessante no Exchanges da Wiley: 

Search Engine Optimization and Your Journal Article: Do you want the bad news first? (aqui).

Veja o resumo que ela apresenta

Here are some highlights:

• Carefully select relevant keywords
• Lead with keywords in the article title
• Repeat keywords 3-4 times throughout the abstract
• Use headings throughout the article
• Include at least 5 keywords and synonyms in the keyword field
• Link to the published article on social media, blogs and academic websites

Interessante também olhar o “manual” que a Wiley preparou  Search Engine Optimization: For Authors que a Wiley (aqui).

Ilustração reproduzida do post citado acima.