sexta-feira, 13 de setembro de 2013

Vaga PD na Scripps: Molecular Basis of Protein Quality Control and Neurodegeneration

SEPTEMBER 2013: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell and Molecular Biology, The Scripps Research Institute (San Diego, California).
Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease. The position available is to elucidate mechanisms and critical biological functions of Listerin, an E3 Ubiquitin Ligase implicated in Protein Quality Control and Neurodegeneration.
We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, an E3 ligase whose function was unknown at that time (Chu et al. 2009). Homozygous lister mice are born normal but exhibit early-onset and progressive neurological and motor dysfunction. The focus of our subsequent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of S. cerevisiae and found that the E3 is ribosome-associated and functions in the quality control of aberrant nascent proteins (Bengtson & Joazeiro 2010). Currently, our lab undertakes different approaches (such as biochemistry, yeast genetics, structural biology, mammalian tissue culture and genomics) to continue characterizing Listerin/Ltn1, and we are well-positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:
Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.

Nature 467:470-3.
Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in

neurodegeneration. PNAS 106:2097-103.
Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin

ligases. Annu Rev Biochem. 78:399-434.
The candidate is expected to be proactive and productive, and should have strong background in biochemistry and molecular biology.
Please send CV, a paragraph on current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro (Email: or Lorraine Lathrop (Email: The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd, La Jolla, CA 92037 

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