quinta-feira, 12 de setembro de 2013

Vaga Pós doutorado na Scripps: Descoberta de drogas anti-cancer

SEPTEMBER 2013: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Molecular and Cell Biology, The Scripps Research Institute (San Diego, California).
Research in the laboratory addresses mechanisms of ubiquitination and the role of E3 ubiquitin ligases in biology and disease. This position is to carry out work as part of a multi-disciplinary collaborative team to (1) develop in vitro assays to identify inhibitors of E3 ligases from small molecule compound collections that we have generated; (2) subsequently validate the identified inhibitors all the way to therapeutic efficacy in animal models (cancer xenografts); and (3) utilize identified inhibitors as tools to study the biology of the target E3 and to elucidate molecular mechanisms of ubiquitination.
Selected references:
Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467:470-3.
Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399-434.
Li W et al. 2008. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3(1):e1487.
The candidate should have strong conceptual and experimental background in biochemistry and molecular biology, including at least some of the following: recombinant protein expression and purification, enzyme kinetics, and mammalian cell culture. Expertise in the mechanistic dissection of signaling or in cancer biology and signaling is also desirable, but not required. He/she should be proactive and productive, have excellent communication skills, and desire to work in a fast-paced, multi-disciplinary collaborative team.
Please send CV, a paragraph of current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro (Joazeiro@scripps.edu) The Scripps Research Institute, CB-163 10550 N Torrey Pines Rd
La Jolla, CA 92037 USA 

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