Pedro Lagerblad de Oliveira, falará sobre: Heme e sinalização celular

O Dr. Pedro Oliveira (CV Lattes) do Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, estará conosco nos dias 03 e 04 de fevereiro.

Dia 03/02/2011 ele participará, como examinador, da Dissertação de Mestrado da estudante do LIMI Nívea Farias Luz, intitulada: “Papel da enzima heme-oxigenase-1 (HO-1) na resposta à infecção por Leishmania chagasi.”

Dia 04/02/2011 ele fará uma palestra sobre os seus estudos para o LIMI/LIP e depois uma discussão sobre o tema com os estudantes envolvidos em projetos a fins. 

Pedro concentra seus esforços de pesquisa em bioquímica e biologia de vetores de doenças, com ênfase no estudo de metabolismo de heme e radicais livres em artrópodos hematófagos e em linhagens mielóides de mamíferos.

Veja o programa abaixo:

Dia	Horário	Atividade
03/02 (5a-f)	14’00	Participação na Dissertação de Mestrado da estudante Nivea Farias Luz
04/02 (6a-f)	09’00	Palestra: "Heme e sinalização celular”
	10’30	Livre para interações com pessoal do LIMI e do LIP

Algumas publicações de Pedro:

Caiaffa, C.D. ; STIEBLER, R. ; Oliveira, M.F. ; Lara, F.A. ; Paiva-Silva, G.O. ; Oliveira, P.L. . Sn-protoporphyrin inhibits both heme degradation and hemozoin formation in Rhodnius prolixus midgut. Insect Biochemistry and Molecular Biology, p. 1-8, 2010

Sartorello, Robson ; Budu, Alexandre ; Bagnaresi, Piero ; Fernandes, Carlos ; Sato, Paloma ; Bueno, Vânia ; Fontes, Marcos ; de Oliveira, Pedro L ; Gabriela ; Alves, Simone ; Netto, Luis ; Catalani, Luiz ; Garcia, Celia . In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells.. Cell Biology International (Print), v. 34, p. 65-859, 2010.

Stiebler, Renata ; Timm, Bruno L. ; Oliveira, Pedro L. ; Hearne, Giovanni R. ; Egan, Timothy J. ; Oliveira, Marcus F. . On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut. Insect Biochemistry and Molecular Biology, p. 284-292, 2010.

Leite, MS ; Thomaz R ; OLIVEIRA, J. H. M. C. ; OLIVEIRA, P. L. ; Meyer-Fernandes, JR . Trypanosoma brucei brucei: Effects of ferrous iron and heme on ecto-nucleoside triphosphate diphosphohydrolase activity?. Experimental Parasitology, v. 121, p. 137-143, 2009.

Gonçalves, Renata L. S. ; Machado, Ana Carolina L. ; Paiva-Silva, Gabriela O. ; Sorgine, Marcos H. F. ; Momoli, Marisa M. ; Oliveira, Jose Henrique M. ; Vannier-Santos, Marcos A. ; Galina, Antonio ; Oliveira, Pedro L. ; Oliveira, Marcus F. ; Hermes-Lima, Marcelo . Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito. Plos One, v. 4, p. e7854, 2009.

LARA, F. A. ; kahn s ; fonseca a ; bahia c ; pinho j ; GRACA-SOUZA, A. V. ; houzel jc ; Oliveira, Pedro L. ; neto vm ; Oliveira, M. F. . On the fate of extracellular hemoglobin and heme in brain. Journal of Cerebral Blood Flow and Metabolism, v. 29, p. 1109-1120, 2009.

POHL, P. C. ; SORGINE, M. H. F. ; LEAL, A. T. ; LOGULLO, C. J. ; OLIVEIRA, P. L. ; VAZ JR, I. S. ; MASUDA, A. . An extraovarian aspartic protease accumulated in tick oocytes with vitellin-degradation activity. Comparative Biochemistry and Physiology. B, Biochemistry & Molecular Biology, v. 151, p. 392-399, 2008.

OLIVEIRA, M. F. ; Gandara AC ; C.M.S. Braga ; J.R. Silva ; Mury FB ; DANSA-PETRETSKI, M. ; MENEZES, D. ; VANNIER-SANTOS, M. A. ; OLIVEIRA, P. L. . Heme crystallization in the midgut of triatomine insects.. Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 146, p. 168-174, 2007.

Citelli M ; Lara, F.A. ; VAZ JR, I. S. ; OLIVEIRA, P. L. . Oxidative stress impairs heme detoxification in the midgut of the cattle tick,. Molecular and Biochemical Parasitology, v. 151, p. 81-88, 2007

Figueiredo RT ; Fernandez PL ; Mourão-Sá ; Porto B N ; Dutra FF ; Alves L T ; OLIVEIRA, M. F. ; GRAÇA-SOUZA, A. V. ; Bozza M T ; OLIVEIRA, P. L. . Characterization of Heme as Activator of Toll-like Receptor 4. Journal of Biological Chemistry (Online), v. 282, p. 20221-20229, 2007

 PAIVA-SILVA, G. O. ; Oliveira, C.C. ; NAKAYASU, E. S. ; MAYA-MONTEIRO, C. ; DUNKOV, B. C. ; MASUDA, H. ; ALMEIDA, I. C. ; OLIVEIRA, P. L. . A novel heme degradation pathway in a blood-sucking insect. PNAS. Proceedings of the National Academy of Sciences of the United States of America, USA, v. 103, n. 00, p. 8030-8035, 2006.

  GRAÇA-SOUZA, A. V. ; MAYA-MONTEIRO, C. ; PAIVA-SILVA, G. O. ; BRAZ, G. ; PAES, M. C. ; SORGINE, M. H. F. ; OLIVEIRA, M. F. ; OLIVEIRA, P. L. . Adaptations against heme toxicity in blood-feeding arthropods.. Insect Biochemistry and Molecular Biology, v. 36, p. 322-335, 2006

Oportunidades de fomento

Oportunidades Vigentes

Edital Fapesb nº 04/2011 - Participação em Evento Científico ou Tecnológico no Exterior (Linha 01) ou em Território Nacional (Linha 02)

Edital Fapesb nº 04/2011 visa incentivar a participação de membros da comunidade científico-tecnológica, vinculados às instituições de ensino superior e/ou pesquisa localizadas no Estado da Bahia, em eventos científicos e/ou tecnológicos, exclusivamente para apresentação de trabalhos de sua autoria, através do financiamento de passagens.

A solicitação de apoio pode ser encaminhada em duas diferentes linhas:

Linha 1: participação em evento científico e/ou tecnológico no exterior; 
Linha 2: participação em evento científico e/ou tecnológico em território nacional.

Preenchimento online do pedido:

Eventos realizados de maio a julho: até as 17h30min do dia 3 de março de 2011; 
Eventos realizados de agosto a outubro: até as 17h30min do dia 19 de abril de 2011; 
Eventos realizados em novembro e dezembro: paté as 17h30min do dia 1º de agosto de 2011. 

Home Page: http://www.fapesb.ba.gov.br/?page_id=219

Edital Fapesb nº 02/2011 - Apoio à Organização de Eventos Científicos ou Tecnológicos

O Edital Fapesb nº 02/2011 destina-se a apoiar a organização e a realização de eventos de natureza científica ou tecnológica, de âmbito local, regional, nacional e internacional, nas diversas áreas do conhecimento, a ocorrer no Estado da Bahia nos meses de agosto a dezembro de 2011.

As propostas serão classificadas em três faixas abaixo distribuídas, associados a todas as áreas do conhecimento:

Faixa 1: eventos não consolidados de natureza científica e/ou tecnológica a ocorrer na Região Metropolitana do Salvador-BA (municípios de Salvador, Lauro de Freitas, Candeias, Camaçari, Dias D'Ávila, Simões Filho, Vera Cruz, Itaparica); 
Faixa 2: eventos não consolidados de natureza científica e/ou tecnológica a ocorrer nas demais cidades do Estado da Bahia; 
Faixa 3: eventos consolidados de natureza científica e/ou tecnológica a ocorrer no Estado da Bahia.

Data Limite: Até as 17h30min do dia 11 de março de 2011.

Home Page: http://www.fapesb.ba.gov.br/?page_id=4553

Edital Fapesb nº 03/2011 - Apoio a Publicação Cientifica e Tecnológica

O Edital Fapesb nº 03/2011 visa incentivar a publicação científica e tecnológica, em especial aquela de natureza inédita, visando difundir conhecimentos, técnicas ou tecnologias que sejam relevantes para o desenvolvimento econômico, social e cultural do Estado da Bahia, através do financiamento à edição de livros (monográficos ou coletâneas), desde que não seriados.

Data Limite: Até as 17h30min do dia 13 de julho de 2011.

Home Page: http://www.fapesb.ba.gov.br/?page_id=4518

ISID Scientific Exchange Fellowship Program

The mission of the International Society for Infectious Diseases (ISID) is to enhance research, prevention, and treatment of infectious diseases, particularly in low resource countries. The Society's programs emphasize the transfer of information and appropriate technology through training and education of health care professionals. 

The ISID Scientific Exchange Fellowship Program was established in 1992 to promote collaboration among researchers in different countries by enabling infectious disease researchers in the formative stage of their career to extend their research experience in institutions outside of their region. These awards are not restricted to physicians and are intended to support young scientists from developing countries in updating their knowledge of new, relevant laboratory techniques or in learning specific skills and techniques. Proposals that enhance the transfer of technologies to geographical areas where they are particularly needed will be favored.

Data Limite: The annual deadline is March 1, and applicants will be notified after June 1.

Home Page: http://www.isid.org/grants/grants_fellowships.shtml

ICGEB Prospective Meeting/Course Organisers Held at ICGEB Affiliated Centres

The International Centre for Genetic Engineering and Biotechnology (ICGEB) conducts innovative research in life sciences for the benefit of developing countries. It strengthens the research capability of its Members through training and funding programmes and advisory services and represents a comprehensive approach to promoting biotechnology internationally. Affiliated Centres are established research institutes in Member States which have attained, or have the potential for, high standard research.

Laboratory courses of up to 10 days' duration are intended to train scientists and technologists in the theory and practice of advanced biotechnology research, as well as to address subjects and priorities of a regional nature. Training courses are to be conducted by the organising institute's staff and invited lecturers.

The programme also accommodates proposals for resarch workshops, symposia and conferences intended to disseminate scientific knowledge and enhance interaction of researchers and policy makers from ICGEB Member States. Research-orientated meetings are generally of two to five days duration.

Data Limite: Complete applications must be sent to the ICGEB Liaison Officer in the applicant’s country of origin by 15 March annually.

Home Page: http://www.icgeb.org/member-states-meetings.html

Boehringer Ingelheim Fonds PhD Scholarships

The Boehringer Ingelheim Fonds is a public foundation - an independent, not-for-profit institution for the exclusive and direct promotion of basic research in biomedicine. It supports researchers and projects aimed to experimentally elucidate basic phenomena of human life and pays particular attention to the promotion of junior scientists. 

The Foundation awards PhD Fellowships to outstanding young scientists who wish to pursue an ambitious PhD project in basic biomedical research in an internationally leading laboratory. The purpose of this program is to promote basic research in biomedicine by providing the best young, up-and-coming scientists with comprehensive support during their PhD phase.

Data Limite: The application must be submitted by one of the respective deadlines of each year (date as per postmark for the paper version): 1 February, 1 June, 1 October.

Home Page: http://www.bifonds.de/scholar/scholar.htm

FMI International PhD Programme

The Friedrich Miescher Institute (FMI) provides an outstanding research environment for studies of biomedical importance. The institute also fosters a lively educational atmosphere having trained hundreds of young scientists at the postgraduate and postdoctoral levels. It offers dedicated programmes for diploma and PhD students as well as research experience to visiting students from abroad. 

The FMI International PhD Program provides advanced, interdisciplinary training in epigenetics, neurobiology and signaling & cancer. PhD students admitted to the program receive theoretical and practical training, and conduct a research project under the supervision of an FMI group leader, monitored by a Thesis Committee of university professors and experts chosen by the student. 

PhD students learn highly advanced techniques from specialists and are introduced into experimental analysis at multiple levels of biological organization. PhD students at the FMI are enrolled at the University of Basel. After successful completion of the research project, submission of a written thesis and a thesis defense, the candidate receives a PhD from theUniversity of Basel.

Together with the Biozentrum of the University of Basel, the Department of Biosystems Science and Engineering (D-BSSE) of the ETH, and the Swiss Tropical Institute (STI), the FMI participates in an international and interdisciplinary graduate teaching program in the areas of:

1. Infection biology; 
2. Neurobiology; 
3. Cell biology; 
4. Developmental biology; 
5. Biophysical chemistry; 
6. Structural biology; 
7. Systems biology; 
8. Bioinformatics.

Data Limite: There are two deadlines each year, in May and December. The next deadline for application is May 5, 2011.

Home Page: http://www.fmi.ch/training/phd/apply/

Elaborado por

Fundação Oswaldo Cruz

Centro de Pesquisas Gonçalo Moniz

Vice-diretoria de Pesquisas e Desenvolvimento Tecnológico

O impacto da elevação do nível do mar em doenças tropicais negligenciadas

Post de Bruno Sangiorgi

A despeito do aquecimento global ser um assunto polêmico, e para muitos ainda controverso, cabe à ciência estar a par das possíveis consequências advindas deste fenômeno. Tendo como pressuposta a sua ocorrência, será inevitável a elevação do nível dos mares decorrente do derretimento das calotas polares. Ao final do século 21, espera-se que haja uma elevação do nível do mar em até 60cm, levando tanto ao recuo da zona costeira quanto à invasão da água marinha em em rios e lagos de água doce, aumentando no interior do continente a quantidade de águas salinas e salobras, respectivamente.

Dentre os muitos problemas decorrentes deste cenário, foi recentemente estudado seu possível impacto na dinâmica dos vetores de doenças infecciosas. Especial atenção foi dada aos insetos que realizam oviposição em água, pois a redução na quantidade de águas doces, associada a profusão de águas salinas e salobras, poderá influenciar na disponibilidade dos locais para oviposição e na sobrevivência das formas imaturas (ovo, larva e pupa). Estas alterações deverão implicar em flutuações na densidade vetorial, influenciando na redução ou expansão das doenças transmitidas.

Umas das hipóteses apresentadas pelos pesquisadores prevê o aumento na densidade de insetos vetores tolerantes à salinidade, bem como novos locais de ocorrência destes vetores. Baseado no fato que muitas espécies vetoras, principalmente dos gêneros Aedes, Anopheles e Culex, apresentam mecanismos fisiológicos e estruturais que permitem a tolerância a salinidade de formas imaturas, é plausível que o acréscimo na quantidade de águas disponíveis para oviposição seja acompanhado pela expansão numérica das populações e colonização de novas áreas alagadas. Esta suposição é corroborada pela expansão populacional de vetores do gênero Anopheles, seguido por surtos de malária, na região costeira da Ásia após o tsunami de 2004, fato que reproduz o que se entende por invasão marítima.

A nível global, a elevação do nível do mar associada ao aquecimento das zonas temperadas tornará estas regiões mais permissivas a sobrevivência dos insetos vetores. Isto poderá implicar na migração de populações dos vetores para o norte e sul do planeta, afetando uma parcela significativa da população mundial, pois mais da metade dela se localiza a pelo menos 60km das regiões costeiras atuais. Deste modo, extrapolando a hipótese apresentada, o surgimento generalizado de novos focos das doenças tropicais negligenciadas ao redor do globo poderá, no futuro, torná-las menos tropicais e negligenciadas.

Refêrencias:

Ramasamy, R., & Surendran, S. (2011). Possible impact of rising sea levels on vector-borne infectious diseases BMC Infectious Diseases, 11 (1) DOI: 10.1186/1471-2334-11-18

Manguin, S., Garros, C., Dusfour, I., Harbach, R., & Coosemans, M. (2008). Bionomics, taxonomy, and distribution of the major malaria vector taxa of Anopheles subgenus Cellia in Southeast Asia: An updated review Infection, Genetics and Evolution, 8 (4), 489-503 DOI: 10.1016/j.meegid.2007.11.004

Do blog Pós-graduando: Dúvidas sobre o preenchimento do Currículo Lattes

O blog Pós-Graduando tem tratado com frequencia do CV Lattes. Veja o texto que publicou recentemente, com resposta de Geraldo Sorte, do CNPq. (aqui)

"Desde que assumiu suas atividades como membro da Comissão da Plataforma Lattes no CNPq, o Prof. Dr. Manoel Barral-Netto tem coletado sugestões e respondido a dúvidas por meio do seu perfil no Twitter e do seu blog. Sempre fico muito contente quando vejo as atividades do cotidiano acadêmico sendo colocadas em discussão. Afinal, sem discussão não há avanço.

O preenchimento do Currículo Lattes é o segundo tema mais discutido pelos leitores aqui no posgraduando.com e em nosso perfil no Twitter, perdendo apenas para a relação [de amor e/ou ódio] entre orientadores/orientados. Por isso, encaminhei ao professor algumas dúvidas dos nossos leitores, que foram respondidas pelo Geraldo Sorte, responsável pela Plataforma Lattes no CNPq.

PG – O campo “Formação Complementar” é freqüentemente preenchido por eventos diversos, que vão desde palestras até MBAs. Que eventos devem ser considerados como “Formação Complementar”? Quais são os critérios para distingui-lo do campo “Participação em eventos”?

GS – O item “formação complementar” é destinado ao cadastro devprogramas de formação, aperfeiçoamento e atividade de extensão que não sejam cursos acadêmicos formais (cursos de extensão, cursos de formação profissional, oficinas, cursos de línguas, etc. )"

Leia o restante diretamente no blog Pós-Graduando (aqui)

Quais os grandes avanços nas ciências da saúde em 2010?

A publicação NIH Research Matters, no seu último número, fez uma recapitulação das matérias publicadas em 2010 e indica o que considera os grande avanços, divididos em três grande tópicos:

Descobertas clínicas;
Avanços médicos promissores;
Avanços no laboratório.

Coloco abaixo as minhas escolhas da lista deles, veja a matéria completa (aqui).

Clinical Breakthroughs

Prevention, Diagnosis and Treatment of Human Disease

Alzheimer's Disease Signature Seen in Spinal Fluid 
Levels of 2 proteins in cerebrospinal fluid might be used to identify people with Alzheimer's disease before they show clinical symptoms. A distinct Alzheimer's signature—reduced levels of a specific beta-amyloid protein and increased levels of a phosphorylated tau protein—was found in 90% of Alzheimer's patients and 72% of people with mild cognitive impairment. The NIH-funded finding could open new opportunities for developing Alzheimer’s therapies.
Research Matters | PubMed

New Test Detects TB in Less than 2 Hours 
An automated test, developed with NIH support, rapidly and accurately detected tuberculosis and drug-resistant TB bacteria. In a study of 1,730 patients, the test identified 98% of all confirmed TB cases in less than 2 hours and up to 90% of TB cases that were missed by a more common diagnostic method. The finding could pave the way for earlier diagnosis and more targeted treatment of this sometimes-deadly disease.
Research Matters | PubMed

Gene Variants Tied to Poor Outcomes with Heart Drug 
Clopidogrel, a widely prescribed anti-clotting drug, was known to be less effective for heart patients with 2 copies of a variant gene, or up to 4% of the population. An NIH-funded study showed that patients with just 1 variant—another 26% of the population—may also be at risk. The finding advances our understanding of how to tailor medications based on genetic makeup.
Research Matters | PubMed

Immunotherapy Boosts Pediatric Cancer Survival A new antibody-based therapy prompted an immune system attack on tumor cells and significantly improved the survival rates of children with neuroblastoma, a deadly nervous system cancer. In an NIH-funded of 226 children with neuroblastoma, the new immunotherapy plus standard therapy raised the survival rate to 66%, compared to 46% for those receiving standard therapy. The study was stopped early because of the positive results.
Research Matters | PubMed

Patient's Whole Genome Reveals Disease and Medication Risks
By evaluating the entire genome of a 40-year-old man, scientists pinpointed gene variants linked to cardiovascular disease and several other conditions in the man’s family, as well as diseases not known to be in his family. Some variants predicted the man’s likely responses to common medications, including certain heart medications. This NIH-funded study provides a glimpse into how whole-genome sequencing might one day be used in the clinic.
Research Matters | PubMed

Best Treatment Differs for Kids With Asthma
Most children who have trouble controlling their asthma with low-dose inhaled corticosteroids show improvement by increasing the dose or adding another medication, an NIH-funded study reported. However, the best option differed for each child. The clinical study of over 150 children identified characteristics, such as ethnicity, that raise the likelihood of one treatment working better than another. The finding highlights the need for a personalized approach to treating pediatric asthma.
Research Matters | PubMed

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Promising Medical Advances

Findings with Potential for Enhancing Human Health

Progress on a Universal Flu Vaccine
NIH researchers developed a method to generate antibodies that attack a diverse array of influenza viruses in animals. The success moves scientists closer to a universal flu vaccine—one that protects against multiple viral strains for several years. After receiving a vaccine that targets a particular viral protein, followed by a booster shot, animals produced broadly neutralizing antibodies. Most were protected from death after exposure to the deadly 1934 flu virus.
Research Matters | PubMed

The Health Benefits of Cutting Salt 
A computer model of heart disease in U.S. adults suggested that reducing salt intake by 3 grams per day could cut the number of new cases of coronary heart disease each year by as many as 120,000, stroke by 66,000 and heart attack by nearly 100,000. It could also prevent up to 92,000 deaths and save up to $24 billion in health care costs a year, the NIH-funded researchers estimated.
Research Matters | PubMed

Where Kids Get Their Empty Calories 
Nearly 40% of the energy consumed by 2- to 18-year-olds comes in the form of "empty" calories, according to a study by NIH scientists. Half of those empty calories come from the solid fats and added sugars in just 6 sources: soda, fruit drinks, dairy desserts, grain desserts, pizza and whole milk. Experts recommend that kids limit their intake of empty calories to 20% or less of their total calories.
Research Matters | PubMed

Preventing Bacterial Infections from Medical Devices
NIH scientists identified a protein that helps bacteria break away from medical devices like catheters and spread throughout the body. By treating mice with antibodies that block the protein, the researchers prevented the bacteriumStaphylococcus epidermidis from spreading from a catheter to most other organs. The finding gives insight into how complex bacterial communities called biofilms cause disease and opens up new avenues for curbing biofilm-related infections.
Research Matters | PubMed

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Insights from the Lab

Noteworthy Advances in Basic Research

Controlling Computers with Your Mind 
A brain-computer interface let people control pictures on a computer screen by activating just a few brain cells. NIH-funded scientists monitored brain cell activity via wires that sent information from patients’ brains to a computer. In a simple computer game, participants were able to use their thoughts to control the images on the monitor nearly 70% of the time. The findings shed light on how single brain cells contribute to attention and conscious thought.
Research Matters | PubMed

Gut Bacteria May Influence Metabolic Syndrome
An NIH-funded study suggested that gut microbes, along with part of the immune system, may contribute to metabolic syndrome. Mice lacking an important immune receptor grew heavier than control mice and developed several features of metabolic syndrome. When gut microbes from these mice were transplanted into control mice, the recipient mice overate, became obese and diabetic. The next step will be to explore how gut microbes affect people's eating behavior.
Research Matters | PubMed

Coaxing the Body's Cells to Repair Damaged Joints 
NIH-supported scientists developed a technique to regenerate damaged leg joints in rabbits. The researchers created porous scaffolds in the shape of leg bone tips and added a gel to aid cartilage development. By 3 to 4 weeks after surgery, the rabbits could move around almost as well as normal rabbits. Within 4 months, both bone and cartilage had regenerated. The accomplishment could point the way toward joint renewal in humans.
Research Matters | PubMed

Stress Hormone Causes Epigenetic Changes 
Researchers found that chronic exposure to a stress hormone altered DNA in the brains of mice, prompting changes in gene expression. NIH-supported scientists found that giving mice a stress hormone caused epigenetic modifications—changes to DNA that don’t alter sequences but influence gene expression—to a gene that has been tied to posttraumatic stress disorder and mood disorders in people. The finding provides clues into how stress might affect behavior.
Research Matters | PubMed