sexta-feira, 11 de fevereiro de 2011

Top 7 in immunology

Estes são os artigos que estão no topo do ranking em imunologia, na F1000, em 3 de fevereiro. O ranking é calculado a cada 30 dias por membros do F100 que lêem e classificam os papers mais importantes da sua área.

Atenção para o paper #5 (Victora et al.), o qual foi apresentado na última reunião da SBI em Porto Alegre, em 2010.

1. How Tregs limit inflammation
T-regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of T-cells involved in killing (effector T-cells) into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared.

L. W. Collison et al., "IL-35-mediated induction of a potent regulatory T cell population," Nat Immunol, 2010. Evaluated by Avinash Bhandoola, Univ Pennsylvania; Christian Engwerda, Queensland Inst of Med Res, Australia; Lieping Chen, Johns Hopkins Univ Sch of Med; David Serreze, The Jackson Lab; Xiaojing Ma, Weill Med Col of Cornell Univ; Stephen Cobbold, Univ Oxford; Stanley Perlman, Univ Iowa. Free F1000 Evaluation

2. Fighters in fat
A new type of immune cell dubbed the "natural helper cell," found around the fat stores of the gut, activates B-cells and produces more Th2-type cytokines than other cells, possibly contributing to allergic immunity, clearance of parasitic worms and wound healing.

K. Moro et al., "Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells," Nature, 463:540-44, 2010. Evaluated by Avinash Bhandoola Univ Penn; John Gordon Foster and Steve Ward, Univ Bath, UK; Troy Randall, Univ Rochester; Dale Umetsu, Children's Hosp Boston, Harvard Med Sch; Dhaya Seshasayee and Flavius Martin, Genentech; James Di Santo, Inst Pasteur, France; Richard Locksley, UCSF. Free F1000 Evaluation
B cell
Image: Wikimedia

3. Directed clean-up
Neutrophils are attracted to an inflamed area in part to help clean-up bruised or dead tissue, but they can also contribute to the inflammation and cause additional damage if overstimulated. Researchers found that a hierarchy of signals directs neutrophils through healthy tissue to their target, and helps limit collateral damage from these cells.

B. McDonald et al., "Intravascular danger signals guide neutrophils to sites of sterile inflammation," Science, 330:362-66, 2010. Evaluated by William A Muller, Northwestern Univ, Feinberg School of Med; Samantha Wang and Karsten Gronert, UC, Berkeley; Sharon Hyduk and Myron Cybulsky, Toronto Gen Hosp, Canada. Free F1000 Evaluation

4. Allergy gets a new look
The role of basophils, a type of white blood cell, in allergic reactions has recently become an area of controversy: While some recent studies support the old dogma that basophils are key components of allergic reaction, this new study adds to a body of literature suggests they are not involved at all -- specifically, that dendritic cells, not basophils, are critical for allergic inflammation.

A.T. Phythian-Adams et al., "CD11c depletion severely disrupts Th2 induction and development in vivo," J Exp Med, 207:2089-96, 2010. Evaluated by Thomas Nutman, NIH; Marc A Williams, US EPA; Booki Min, Cleveland Clinic Foundation; Eric Denkers, Cornell Univ. Free F1000 Evaluation

5. Tracking B-cell movement
By applying GFP technology in a new way, authors tracked B-cell maturation in the lymph nodes as the cells move from an area of rapid proliferation to an area where B cells that produce the best antibodies are selected, and back again, and found an essential role of T helper cells in this transition.

G.D. Victora et al., "Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter," Cell, 143:592-605, 2010. Evaluated by Yinan Wang and Deepta Bhattacharya, Washington Univ in St. Louis; Naomi Harwood and Facundo Batista, Cancer Res UK, London Res Inst; Kai-Michael Toellner, Univ Birmingham, UK. Free F1000 Evaluation

6. Cancer suppresses immune response
Neutrophils, usually thought of as the first responders during infection, can suppress the inflammatory response to cancer when exposed to peptides from tumor cells, demonstrating a new way for tumors to evade the immune system, and hinting at novel targets for cancer immunotherapies.

C. De Santo et al.,"Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A" Nat Immunol, 11:1039-46, 2010. Evaluated by Dale Umetsu, Children's Hosp Boston, Harvard Med Sch; Alberto Mantovani, Inst Clin Humanitis, Univ Milan, Italy; William Seaman, UCSF. Free F1000 Evaluation

7. Viruses fueled by recycled materials
The Dengue virus co-opts autophagy, one of the cell's recycling mechanisms, in order to reuse host lipids that it then uses to drive its own replication, explaining where viruses get the energy to support their division.

N.S. Heaton and G. Randall, "Dengue virus-induced autophagy regulates lipid metabolism," Cell Host Microbe, 8:422-32, 2010. Evaluated by Muriel Mari and Fulvio Reggiori, Univ Med Cen Utrecht, Netherlands; P'ng Loke, NYU Langone Med Cen; Joeli Marrero and Sabine Ehrt, Weill Cornell Med Col. Free F1000 Evaluation

Leia mais: Top 7 in immunology - The Scientist

Nenhum comentário:

Postar um comentário